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Tumor patients included those with nose, breast, stomach and liver cancers, while Emergency Room patients had various pathologies. Patients were randomly assigned to receive a "sciatic nerve press" in which pressure was applied simultaneously to the sciatic nerves at the back of both thighs, or a "placebo press" in which pressure was applied to a parallel region on the front of the thighs.

Each fist applied a pressure of 11 — 20 kg for 2 minutes. Patients rated their level of pain before and after the procedure. The "sciatic nerve press" produced immediate relief of pain in all patient groups. Emergency patients reported a Two minutes of pressure on both sciatic nerves produced immediate significant short-term conduction analgesia. This technique is a convenient, safe and powerful method for the short-term treatment of clinical pain associated with a diverse range of pathologies.

Human beings have long suffered from pain caused by diseases. In medicine, pain is one of the most common reasons for patients to seek care. Analgesics used in current practice have drawbacks such as delays in acquisition and lag-times for effect after administration. In addition, many commonly used analgesics have considerable side-effects [ 1 - 4 ].

Many non-drug analgesic interventions have been used to help manage pain, including acupuncture, cryoanalgesia, transcutaneous electrical nerve stimulation TENS , exercise, and music therapy, etc. Though literature reviews document the efficacy of some non-drug analgesic interventions [ 5 , 8 , 9 ], their use are usually restricted to some pain centers, and, the clinical effectiveness of some analgesic methods are controversial [ 10 - 12 ].

We recently published a preliminary report on a new analgesic method, a 2-min sciatic nerve press, which immediately relieved pain brought on by various dental and renal diseases [ 13 ]. The technique is simple, can be used any time, any place, immediately upon the onset of pain including outside of a hospital setting. No side effects have yet been seen. The present study examined whether the technique worked on more pathologies, and whether pain relief extended to up to one hour. The study was a randomized, single-blinded, placebo-controlled, parallel-group trial consisting of patients treated between October and May at four hospitals in China.

Written informed consent was obtained from each participating patient. Patients were divided into "sciatic press" and "placebo press" groups. Instructions and explanations were equally provided to all patients. Patients were informed that the experiments were designed to test whether the methods were effective for pain relief. Patients were advised that they could discontinue participation in the study at any time without penalty, and that their healthcare treatment would not otherwise be affected.

After informed consent was obtained, the participating doctor s or assistants taught the patients how to evaluate pain using a visual analogue scale VAS , where pain scored from "0" for no pain, to "10" for most pain. Thereafter, randomization of patients to the "sciatic press" or "placebo press" group was performed using the method of Random Permuted Blocks. The three stages of the test were then described to each patient: baseline pain rating, 2 min of leg pressure while lying down, and post-pressure pain rating at the specified times.

Two test designs were used. For Emergency patients, pain was rated once after pressure application.

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In contrast, renal, dental and tumor patients underwent the 60 min test in which pain was rated at min intervals for a period of one hour after pressure application. In this context, the '0 min' point indicated the time at which the 2-min leg pressure stopped and the post-pressure pain rating stage commenced. The baseline pain rating and leg pressure stages were identical for the two types of tests. This manipulation technique has been previously described in detail [ 13 ].

Briefly, 2 min of pressure with the dorsal, proximal phalangeal surface of the fists not the knuckles or finger tips was applied simultaneously to the sciatic nerve sites or the placebo location on both legs. For the "sciatic nerve press", 11 to 20 kg of pressure was applied to the sciatic nerves on the back of the thighs with each fist, while patients lay prone. For the "placebo press", the same pressure was applied to a parallel spot on the front of the thighs, while patients lay supine.

Patients then stood and rated their pain using a visual analogue scale table. The amount of force applied within the range of 11—20 kg depended on the patient body type, with heavily muscled large-bodied patients receiving higher pressures than thin patients.

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Doctors learned the pressure force applied by repeatedly pressing on a weighted balance. A The location of the pressure areas on the sciatic nerve. B The gesture for applying fist pressure.

The inclusion criterion was any patient who was feeling pain during a clinic visit to the Emergency room, Renal, Dental, or Oncology Clinics. Exclusion criteria were age less than 15 years, emotional instability, or administration of another analgesic within 12 hours of the test. For enrolled patients, the dental diseases included acute pulpitis and periapical abscesses. While Emergency Room enrollees had various pathologies.

No patients had previously been treated with the sciatic press method.

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For tumor patients, analgesics were discontinued 11—13 hours prior to the test, and the study began when patients reported they had moderate-to-severe pain. Of the solicited patients, 57 refused to join and 37 were considered ineligible, leaving patients aged from 15 — 80 years to participate in the study.

Of those , two renal patients in the placebo group withdrew in the middle of the 60 min test stating that the pain was too severe to continue. Renal, dental and oncology patients were analyzed as one group in terms of relief of pain.

Emergency room patients were analyzed separately, and without pathology categorization. The baseline VAS scores and age of the participants were compared between the "sciatic press" and "placebo press" groups using t-tests. Categorical data were analyzed using chi-square, or Fisher Exact tests. In terms of pain relief, changes from baseline were assessed using paired t -tests for both groups. Comparisons with the "placebo press" groups were performed using an analysis of covariance procedure, with adjustment for baseline VAS score, gender and age.

All statistical analyses were performed using SPSS statistical software release Following application of the "sciatic press" technique, patients recorded a Pain relief in emergency patients. Pain was reduced by The 60 min test for the combined group of renal, dental and oncology patients. Mechanical pressure can cause nerve abnormalities.

A number of studies have reported the effect of pressure on nerves using different force levels and time periods of up to several weeks [ 14 - 21 ]. In animal models, pressure studies usually involve surgically exposed nerves [ 16 , 17 , 22 ]. However, the present method uses a much shorter time period, two minutes for the pressure on the intact skin. Thus far, the method has been applied to over subjects across 10 hospitals and universities, and there have been no reports of adverse side-effects.

The type of acute pressure applied in this technique 11 — 20 kg by each fist — mmHg for up to 2 min is not uncommon in daily activities, especially for people involved in sports or heavy manual labor.

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However, nerve injuries as a result of this procedure remain a possibility, and must be taken into account in future studies. The present technique does not involve chronic pressure on nerves, of which even a very small amount could cause severe nerve dysfunction. For example, chronic pressure on the sciatic nerve by internal tension of the obturator muscle or through anatomical abnormalities in the piriformis muscle could cause pain [ 23 - 26 ].

Surgery to relieve the muscle pressure results in immediate pain relief [ 23 , 26 - 28 ]. The present study was single-blinded rather than double-blinded as the method is highly effective for pain relief, and doctors could easily identify the placebo or the active treatment during the test. After patients reported pain scores, patients themselves recorded their pain assessments on a VAS table, or in some cases, had the doctors record the VAS score.

However, it would be a stronger study to have employed a blinded observer, which we will include in our future studies. To our knowledge, no clinical studies have reported on the use of pressure stimulation of the anterior or posterior thigh area for pain relief. The study design ensured no patients had previously undergone this technique, and we believe the 'blinding' procedures remained secure during testing.

The pressure of 11 — 20 kg with each fist was chosen based on pilot studies using Chinese patients. Such a pressure range may differ for Western populations given the difference in average body size. The present study showed that Emergency patients had a mean baseline VAS score of 7. Similarly, our previous study showed that renal patients had a mean baseline VAS score of 7.

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The previous study also showed that dental patients had a baseline VAS score of 6. These data suggest that the analgesic effect may correlate with the baseline pain score. However, the present study was not comprehensive enough to make such a statistical connection, and this hypothesis awaits further testing in future larger studies.

In the "placebo press" group undergoing the 60 min test, VAS scores decreased markedly in later time periods For this study setting, we cannot rule out the total or partial contribution of a placebo effect, or some anterior nerve stimulation to the late drop. Pain discontinuity could also be contributing partially. Stimulation of peripheral nerves elevates the pain threshold [ 29 - 32 ]. According to the Gate Control Theory of Pain [ 33 ], stimulation of large-diameter afferent fibers can inhibit the transmission of nociceptive information from the dorsal horn to higher brain centers.

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This inhibition occurs rapidly and is thought to involve the wide dynamic range WDR neurons [ 34 - 36 ]. The resulting analgesic effect is considered to be a short-lasting, segmental inhibition of pain [ 37 - 39 ]. This theory may explain the rapid pain relief observed in some situations.

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However, the pain relief created by the present method is not limited to the segmental level, but occurs throughout the body. Also, significant pain relief lasted for 60 minutes. These observations suggest possible activation of multiple inhibitory systems. Another mechanism possibly involved is activation of the endogenous opioid system.

Pinch press of the rat sciatic nerve with a vascular clip pinch force g caused attenuation of WDR neuron responses to various innocuous and noxious stimuli [ 41 ]. While the WDR neuron response to superficial peroneal nerve stimulation was shown to increase in cats when the sciatic nerve was under a clip pressure with a pinch force g, the response was inhibited when using low frequency stimulation 0.